A 31-year-old man presenting with an 18-month history of sexual dysfunction resulting from severe adult-onset IHH (LH U/L, FSH U/L, T nmol/L). Initial therapy with 50 mg of clomiphene citrate (CC) three times a day for 7 days, with overnight LH pulse profiling and 9 am T levels evaluated at baseline and on completion. A 2-month washout period, followed by low-dose maintenance therapy (25-50 mg/d) for 4 months.
MAIN OUTCOME MEASURE(S):Baseline and stimulated T levels and LH pulsatility; effect on sexual function.
RESULT(S):Clomiphene therapy resulted in complete normalization of pulsatile gonadotropin secretion, serum T level, and sexual function. CONCLUSION(S):Isolated hypogonadotropic hypogonadism may result from an acquired defect of enhanced hypothalamic sensitivity to E-mediated negative feedback. Whereas direct T replacement therapy can further suppress endogenous gonadotropin secretion, treating IHH men with gonadotropins can stimulate endogenous T secretion and enhance fertility potential. On theoretical grounds, reversal of gonadotropin deficiency with CC might be expected to have a similar biological effect.
Most of you on here that are posting about a womens insecurites – you’re obviously not reading or understanding what we are writing… I am 100% comfortable with my body and sexual needs. i love trying new things and really getting into sex… my partner and i were having sex atleast twice a day for the first year… then alteast 5 days a week for the following 2 years… now going on to our 4th year.. he’s really starting to make me question our relationship… as mentioned in the rest of the posts – we now only have sex mayyyybe once a week.. my sex drive has gone through the roof but my man is either too tired, too lazy to return “the favour” or litterally just laughs and says “maybe i should take more testosterone” jokingly…. however… i find it funny that he has the time and effort to scope the internet for porn but ALSO now youtube just to scope sexy chicks!
Testosterone is significantly correlated with aggression and competitive behaviour and is directly facilitated by the latter. There are two theories on the role of testosterone in aggression and competition.  The first one is the challenge hypothesis which states that testosterone would increase during puberty thus facilitating reproductive and competitive behaviour which would include aggression.  Thus it is the challenge of competition among males of the species that facilitates aggression and violence.  Studies conducted have found direct correlation between testosterone and dominance especially among the most violent criminals in prison who had the highest testosterone levels.  The same research also found fathers (those outside competitive environments) had the lowest testosterone levels compared to other males.