A subpopulation of patients with asthma may have aspirin-sensitive asthma which may include chronic rhinosinusitis complicated by nasal polyps ; severe, potentially fatal bronchospasm; and/or intolerance to aspirin and other NSAIDs. Because cross-reactivity between aspirin and other NSAIDs has been reported in such aspirin-sensitive patients, CELEBREX is contraindicated in patients with this form of aspirin sensitivity [see CONTRAINDICATIONS ]. When CELEBREX is used in patients with preexisting asthma (without known aspirin sensitivity), monitor patients for changes in the signs and symptoms of asthma.
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Assembly language programmers must be aware of hidden side effects — instructions that modify parts of the processor state which are not mentioned in the instruction's mnemonic. A classic example of a hidden side effect is an arithmetic instruction that implicitly modifies condition codes (a hidden side effect) while it explicitly modifies a register (the overt effect). One potential drawback of an instruction set with hidden side effects is that, if many instructions have side effects on a single piece of state, like condition codes, then the logic required to update that state sequentially may become a performance bottleneck. The problem is particularly acute on some processors designed with pipelining (since 1990) or with out-of-order execution . Such a processor may require additional control circuitry to detect hidden side effects and stall the pipeline if the next instruction depends on the results of those effects.