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Inducers of CYP enzymes: Potential pharmacokinetic interaction (decreased plasma concentrations of risperidone). 1 103 Increase oral risperidone dosage up to twice original dosage when administered concurrently with enzyme inducers (., CYP3A inducers); a reduction in oral risperidone dosage may be necessary when the enzyme inducer is discontinued. 1 Patients receiving IM risperidone may need dosage increase or supplemental oral risperidone when therapy with an enzyme inducer is initiated; consider reducing IM risperidone dosage 2–4 weeks before discontinuance of the enzyme inducer. 103 (See Specific Drugs under Interactions.)

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