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The presence and severity of akathisia can be measured using the Barnes Akathisia Scale , [27] [28] which assesses both objective and subjective criteria. [27] Precise assessment of akathisia is problematic, as it is difficult to differentiate from a multitude of disorders with similar symptoms. In a study of movement disorders induced by neuroleptics, akathisia was found in only 26% of patients originally diagnosed with akathisia. [11] The primary distinguishing features of akathisia in comparison with other syndromes are primarily subjective characteristics, such as the feeling of inner restlessness. [29] Akathisia can commonly be mistaken for agitation secondary to psychotic symptoms or mood disorder , antipsychotic dysphoria, restless legs syndrome (RLS), anxiety, insomnia , drug withdrawal states, tardive dyskinesia , or other neurological and medical conditions. [17]

American Charles Osborne had hiccups for 68 years, from 1922 to February 1990, [24] and was entered in the Guinness World Records as the man with the longest attack of hiccups, an estimated 430 million hiccups. [25] In 2007, Florida teenager Jennifer Mee gained media fame for hiccuping around 50 times per minute for more than five weeks. [26] [27] Christopher Sands, a Briton, hiccupped an estimated 10 million times in a 27-month period from February 2007 to May 2009. His condition, which meant that he could hardly eat or sleep, was eventually discovered to be caused by a tumor on his brain stem pushing on nerves causing him to hiccup every two seconds, 12 hours a day. His hiccups stopped in 2009 following surgery. [28]

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