At least one study reports the onset of personality changes, including increased alcohol consumption, after the use of steroids, but notes that the degree of violence experienced was markedly more severe than in previous episodes in which only alcohol was implicated (Conacher 1989) Wesley had supposedly been sober since his treatment at Briarwood in 1986, but began drinking again as his steroid abuse increased. Several other studies indicate that depression and suicidal ideation often accompany the feelings of uncontrollable violence and paranoia experienced by steroid users (Perry 1997). In fact, testosterone, which was once used to treat depression is now known to cause it (Corrigan 1996).
The first major question to be addressed regards how the ethical analysis of risk was understood by the members of the National Commission. The National Commission sat from 1975 to 1978 and issued a total of ten reports on differing aspects of human subjects research. The National Commission's work represents the first sustained in-depth exploration of the moral analysis of risk in research. As such, it has had a lasting influence on research ethics scholarship and federal regulation. Little recognized is the fact that the National Commission's views on risk analysis evolved over its four-year term. Three distinct views on the ethical analysis of risks and potential benefits in research can be found in the National Commission's opus: analysis of entire protocols; analysis of protocols with particular components; and analysis of components.