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In the pre-marketing controlled clinical studies and their open extensions (2,423 patients with median duration of follow-up of approximately 18 months), % of patients were discontinued due to adverse reactions. The most common adverse reactions that led to treatment discontinuation were: gastrointestinal disorders (%), myalgia (%), and arthralgia (%). The most commonly reported adverse reactions (incidence ≥5%) in Simvastatin controlled clinical trials were: upper respiratory infections (%), headache (%), abdominal pain (%), constipation (%), and nausea (%).

Maple Syrup Urine Disease (MSUD) is a condition that results from improper metabolism of branched-chain amino acids. The aromatic in fenugreek, sotolon, may be used as a diagnostic criteria for MSUD as it exists in the urine of those persons with this metabolic defect and gives the characteristic sweet-scent. [14] It normally does not appear in healthy person's urine due to no dietary intake, but may appear in those who drink or consume fenugreek, leading to a false diagnosis. [90] Maternal consumption of sotolon can also transfer into the baby after birth, and cause trans-generational false diagnosis. [91]

Konstantinos Vasilis Petrides ("K. V. Petrides") proposed a conceptual distinction between the ability based model and a trait based model of EI and has been developing the latter over many years in numerous publications. [34] [49] Trait EI is "a constellation of emotional self-perceptions located at the lower levels of personality." [49] In lay terms, trait EI refers to an individual's self-perceptions of their emotional abilities. This definition of EI encompasses behavioral dispositions and self-perceived abilities and is measured by self report , as opposed to the ability based model which refers to actual abilities, which have proven highly resistant to scientific measurement. Trait EI should be investigated within a personality framework. [50] An alternative label for the same construct is trait emotional self-efficacy .

Eq side effects

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