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Extracts produced no adverse effects in mice when administered intravenously. 40 Cyanogenesis from species P. edulis has been suggested. 48 The plant's known actions may reduce arterial pressure affecting circulation and increasing respiratory rate. 8 There are no controlled human trials using single herb preparations of Passiflora extracts before the mid-1990s. 49 There have been cases of vasculitis 50 and altered consciousness in 5 patients taking the herbal product Relaxir , produced mainly from P. incarnata fruits. 51 Occupational asthma and rhinitis may occur from the species P. alata , which was substantiated by skin testing and Western blotting in vivo and in vitro studies. 52

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